Clinical depression is a recurrent illness requiring treatment and often hospitalization. Nearly 50% of people who have an episode of major depression will have a recurrence within 2-3 years. Being able to prevent the recurrence of depression in people who are at risk for the disease would go a long way to alleviate the pain and suffering of patients.
During the 1980’s the federal government, through the National Institutes of Health (NIH), sponsored a large clinical trial to evaluate two drugs for depression. There were 3 treatment groups. Patients received either Imipramine (Imip), Lithium (Li), or a Placebo (Pl). Researchers randomly assigned patients to one of the 3 treatment groups and followed them for 2-4 years to track any recurrences of depression.
(Prien et al., Archives of General Psychiatry, 1984).
Summary statistics for AcuteT:
Group by: Treat
| Treat | n | Mean | Variance | Std. dev. | Std. err. | Median | Range | Min | Max | Q1 | Q3 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 37 | 172.62162 | 6446.7973 | 80.29195 | 13.199915 | 173 | 393 | 48 | 441 | 114 | 211 |
| 1 | 38 | 183.65789 | 6782.1771 | 82.353974 | 13.359579 | 166.5 | 381 | 47 | 428 | 131 | 212 |
| 2 | 34 | 202.11765 | 10590.168 | 102.90854 | 17.648669 | 163.5 | 442 | 70 | 512 | 140 | 246 |
Variables
- Hospt: Which hospital the patient was from: Labeled 1, 2, 3, 5 or 6
- Treat: 0=Lithium; 1=Imipramine; 2=Placebo
- Outcome: 0=Success 1=Failure (recurrence of depression)
- Time: Number of weeks until a recurrence (if outcome=1) or until study ended (if outcome=0)
- AcuteT: How long the patient was depressed before the start of the current study, measured in days
- Age: Age in years
- Gender: 1=Female 2=Male
example for soultion at the word file
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